Preferred Label : Bcl-2 Inhibitor ABBV-623;
NCIt synonyms : BCL2 Inhibitor ABBV-623;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
Bcl-2 inhibitor ABBV-623 targets, binds to and inhibits the activity of Bcl-2. This
restores caspase-mediated apoptosis in tumor cells. Bcl-2 is overexpressed in many
cancers and plays an important role in the negative regulation of apoptosis. Its expression
is associated with increased drug resistance and tumor cell survival.;
Molecule name : ABBV 623; ABBV-623;
NCI Metathesaurus CUI : CL1662768;
Origin ID : C180411;
UMLS CUI : C5556349;
Semantic type(s)
- concept_is_in_subset
- has_target
