NCIt definition : An orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell
lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon
oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2.
This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers
and plays an important role in the negative regulation of apoptosis; its expression
is associated with increased drug resistance and tumor cell survival.;
UNII : OSL3FEZ1IF;
CAS number : 2180923-05-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2180923-05-9
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Currated CISMeF NLP mapping