Preferred Label : Eiletoclax;
NCIt definition : An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2),
with potential pro-apoptotic and antineoplastic activities. Upon oral administration,
eiletoclax targets and binds to the P2 pocket of Bcl-2, thereby inhibiting the activity
of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed
in many cancers and plays an important role in the negative regulation of apoptosis;
its expression is associated with increased drug resistance and tumor cell survival.;
Molecule name : ZE 50-0134; ZE50-0134;
Origin ID : C214971;
concept_is_in_subset
- has_target
