Nuclear Mitotic Apparatus Protein 1

Preferred Label : Nuclear Mitotic Apparatus Protein 1;

NCIt synonyms : NUMA; NUMA1; SP-H Antigen; NuMA Protein; Nuclear Matrix Protein-22; NMP-22; Nuclear Mitotic Apparatus Protein-1;

NCIt definition : Nuclear mitotic apparatus protein 1 (2115 aa, 238 kDa) is encoded by the human NUMA1 gene. This protein may play a role in the formation of the mitotic spindle.;

NCIt note : Nuclear Mitotic Apparatus Protein 1 is a structural component of the nucleus containing the largest known protein coiled-coil region, present throughout the interphase nucleus, and localized to the mitotic spindle apparatus. Required for organizing mitotic spindle poles, NUMA1 also appears to have a role in nuclear reassembly in late mitosis. NUMA C-terminal region specifically interacts with nuclear transport factor Importin-beta, which inhibits microtubule aster assembly.;

Details

Origin ID

C33985;

UMLS CUI

C1335072;

OMIM relation
- Nuclear mitotic apparatus protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- NUMA1 protein, human [MeSH concept]
- NUMA1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- NUMA1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_is_element_in_pathway
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Mitotic Spindle Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Mitosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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