" /> BIRC3 wt Allele - CISMeF





Preferred Label : BIRC3 wt Allele;

NCIt synonyms : Baculoviral IAP Repeat-Containing 3 Gene; RNF49; CIAP2; Apoptosis Inhibitor 2 Gene; HIAP1; API2; Baculoviral IAP Repeat-Containing Protein 3 Gene; hiap-1; MIHC; Baculoviral IAP Repeat Containing 3 wt Allele; IAP Homolog C Gene; Mammalian IAP Homolog C Gene; MALT2; c-IAP2;

NCIt definition : Human BIRC3 wild-type allele is located in the vicinity of 11q25 and is approximately 14 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 3, is involved in apoptotic inhibition by serum deprivation.;

NCIt note : BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.; The BIRC3 gene is involved in a chromosomal translocation t(11;18)(q21;q21) with the MALT1 gene in mucosa-associated lymphoid tissue lymphomas.;

GenBank Accession Number : NM_001165;

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07/05/2025


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