" /> CDK11B wt Allele - CISMeF





Preferred Label : CDK11B wt Allele;

NCIt synonyms : CDC2L1 wt Allele; CLK-1; Cell Division Cycle 2-Like 1 Gene; PK58; p58; p58CLK-1; p58CDC2L1; Cyclin-Dependent Kinase 11B wt Allele; CDK11-p110; CDC2L1; CDK11; CDK11-p58; Cell Division Cycle 2-Like 1 (PITSLRE Proteins) Gene; CDK11-p46; PITSLREA;

NCIt definition : Human CDK11B wild-type allele is located in the vicinity of 1p36.33 and is approximately 31 kb in length. This allele, which encodes cyclin-dependent kinase 11B protein, plays a role in proliferation regulation, apoptosis and is essential for eukaryotic cell cycle control. The allele is deleted or altered frequently in neuroblastoma with amplified MYCN genes.;

NCIt note : CDK11B is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. The gene can also be cleaved by caspases and play roles in cell apoptosis. A large number of alternatively spliced variants of this gene exist.; CDK11A and CDK11B encode almost identical proteins. (UniProt);

GenBank Accession Number : NM_004526;

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12/05/2024


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