Receptor-Interacting Serine/Threonine-Protein Kinase 2

Preferred Label : Receptor-Interacting Serine/Threonine-Protein Kinase 2;

NCIt synonyms : CARD-Containing IL-1 Beta Ice-Kinase; CARD-Containing Interleukin-1 Beta Converting Enzyme Associated Kinase; RIP2; RIPK2; RIP-Like Interacting CLARP Kinase; Receptor Interacting Protein 2; Receptor-Interacting Protein 2; RIP-Like-Interacting CLARP Kinase; EC 2.7.10.2; Tyrosine-Protein Kinase RIPK2; EC 2.7.11.1; Receptor-Interacting Serine/Threonine Protein Kinase 2; Receptor-Interacting Serine-Threonine Protein Kinase-2;

NCIt definition : Receptor-interacting serine/threonine-protein kinase 2 (540 aa, 61 kDa) is encoded by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis and inflammation.;

NCIt note : Receptor-interacting serine/threonine-protein kinase 2 also has tyrosine kinase activity. (UniProt); Receptor-interacting serine/threonine-protein kinase 2 contains 1 CARD domain, activates NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8. RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A and TNRFSF5/CD40 receptor complexes.;

Details

Origin ID

C29872;

UMLS CUI

C1447644;

Currated CISMeF NLP mapping
- Receptor-Interacting protein Serine-Threonine kinase 2 [MeSH Descriptor]
- Receptor-Interacting protein Serine-Threonine kinase 2 [MeSH concept]
OMIM relation
- Receptor-interacting serine/threonine kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RIPK2 protein, human [MeSH concept]
- RIPK2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RIPK2 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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