" /> BIRC2 wt Allele - CISMeF





Preferred Label : BIRC2 wt Allele;

NCIt synonyms : HIAP2; Baculoviral IAP Repeat-Containing 2 wt Allele; CIAP1; MIHB; Mammalian IAP Homolog B; API1;

NCIt definition : Human BIRC2 wild-type allele is located in the vicinity of 11q22 and is approximately 30 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 2, plays a role in the inhibition of apoptosis through caspase inactivation.;

NCIt note : BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) protein family that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.;

GenBank Accession Number : NM_001166;

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31/05/2025


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