NCIt definition : Human BIRC2 wild-type allele is located in the vicinity of 11q22 and is approximately
30 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein
2, plays a role in the inhibition of apoptosis through caspase inactivation.;
NCIt note : BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer
of free radicals. The protein encoded by this gene is a member of the inhibitor of
apoptosis (IAP) protein family that inhibits apoptosis by binding to tumor necrosis
factor receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like
proteases. The amino acid sequence predicts three baculovirus IAP repeat domains and
a ring finger domain.;