BCL2L1 wt Allele

Preferred Label : BCL2L1 wt Allele;

NCIt synonyms : BCL2-Like 1 wt Allele; BCLX; BCL2-Related Gene;

NCIt definition : Human BCL2L1 wild-type allele is located in the vicinity of 20q11.1 and is approximately 1 kb in length. This allele, which encodes apoptosis regulator Bcl-X protein, is involved in apoptotic regulation.;

NCIt note : BCL2L1 can function as a BCL2-independent regulator of programmed cell death (apoptosis). Alternative splicing resulted in 2 distinct BCLX mRNAs. The protein product of the larger mRNA (BCLXL) was similar in size and predicted structure to BCL2. It inhibits cell death upon growth factor withdrawal at least as well as BCL2 in a transfected IL3-dependent cell line. On the other hand, the smaller mRNA species (BCLXS) encodes a protein that inhibits the ability of BCL2 to enhance the survival of growth factor-deprived cells.;

GenBank Accession Number : NM_001191;

Details

Origin ID

C49420;

UMLS CUI

C1704960;

OMIM relation
- Bcl2-like 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 20: 29774317-29715924 [NCIt concept]
gene_in_chromosomal_location
- 20q11.1 [NCIt concept]
gene_is_element_in_pathway
- AIF Pathway [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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