Bcl-2-Interacting Killer

Preferred Label : Bcl-2-Interacting Killer;

NCIt synonyms : BCL2-Interacting Killer; BP4; Apoptosis-Inducing NBK; BIK; BIP1; BCL2-Interacting Killer Protein;

NCIt definition : Bcl-2-interacting killer (160 aa, 18 kDa) is encoded by the human BIK gene. This protein plays a role in apoptosis.;

NCIt note : This protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM);

Details

Origin ID

C21203;

UMLS CUI

C1332394;

OMIM relation
- Bcl2-interacting killer [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BIK Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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