Truncated BID - CISMeF

Preferred Label : Truncated BID;

NCIt synonyms : Truncated BH3-Interacting Domain Death Agonist; tBID;

NCIt definition : Truncated BID is encoded by the human BID gene and is a C-terminal peptide that results from caspase-8 cleavage of the BH3-interacting domain death agonist protein. This protein fragment localizes with the mitochondrial membrane and can stimulate the release of cytochrome c and promote the progression of apoptosis.;

NCIt note : The p11 form of truncated BID is lacking the BH3 domain. (UniProt); Tumor necrosis factor induces a caspase-8-mediated cleavage of p22 BH3-interacting domain death agonist into a major p15 and minor p13 and p11 products. Once cleaved, the products become associated with the mitochondrial membrane. (UniProt);

Details

Origin ID

C104460;

UMLS CUI

C3641819;

OMIM relation
- Bh3-interacting domain death agonist [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- BID Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Regulatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- BCL-2 Family Protein [NCIt concept]
- Protein Fragment [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]

Keyword's position in hierarchy(ies) :

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