Signal Transducer and Activator of Transcription 1-Alpha/Beta

Preferred Label : Signal Transducer and Activator of Transcription 1-Alpha/Beta;

NCIt synonyms : STAT1; Signal Transducer and Activator of Transcription 1; Transcription Factor ISGF-3 Components p91/p84; Signal Transducer and Activator of Transcription-1;

NCIt definition : Signal transducer and activator of transcription 1-alpha/beta (750 aa, 87 kDa) is encoded by the human STAT1 gene. This protein plays a role in signal transduction, immune responses and transcriptional regulation.;

NCIt note : The amino acid number and apparent molecular weight listed is for the alpha isoform. The beta isoform is 712 and approximately 83 kDa. (UniProt);

Details

Origin ID

C28659;

UMLS CUI

C1432814;

Automatic exact mappings (from CISMeF team)
- STAT1 transcription factor [MeSH concept]
- Signal transducer and activator of transcription 1 [OMIM gene]
- signal transducer and activator of transcription 1 [ORDO Gene]
- signal transducer and activator of transcription 1 [HGNC gene]
- stat1 transcription factor [MeSH Descriptor]
OMIM relation
- Signal transducer and activator of transcription 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- STAT1 protein, human [MeSH concept]
- STAT1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- STAT1 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Signal Transducer and Activator of Transcription [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis DNA Damage Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- IFN Alpha Signaling Pathway [NCIt concept]
- IFN Gamma Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- IL22 Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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