IFN Alpha Signaling Pathway

Preferred Label : IFN Alpha Signaling Pathway;

Alternative definition : BIOCARTA: Interferon alpha plays a role in viral infections. Signaling takes place through an IFN receptor complex consisting of two alpha chains (type I receptor) complexed with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ifnaPathway;

Details

Origin ID

C39111;

UMLS CUI

C1512582;

Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Arginine-Vasopressin [NCIt concept]
- Interferon Alpha-1/13 [NCIt concept]
- Interferon Alpha/Beta Receptor 1 [NCIt concept]
- Interferon Alpha/Beta Receptor 2 [NCIt concept]
- Non-Receptor Tyrosine-Protein Kinase TYK2 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 2 [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
pathway_has_gene_element
- AVP wt Allele [NCIt concept]
- IFNA1 wt Allele [NCIt concept]
- IFNA13 wt Allele [NCIt concept]
- IFNAR1 wt Allele [NCIt concept]
- IFNAR2 wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- STAT2 wt Allele [NCIt concept]
- TYK2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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