Interferon Alpha/Beta Receptor 2

Preferred Label : Interferon Alpha/Beta Receptor 2;

NCIt synonyms : Alpha-Beta-Omega Interferon Receptor-2; IFN-R; IFN-Alpha-REC; Interferon Alpha-Beta Receptor; Type I Interferon Receptor; Interferon Alpha-Beta Receptor-2; IFNABR; Interferon Alpha-Beta Receptor Beta Chain; Interferon-Alpha/Beta Receptor Beta Chain; Type I Interferon Receptor 2; IFN-Alpha Binding Protein; Interferon Alpha Binding Protein; IFN-Alpha/Beta Receptor 2;

NCIt definition : Interferon alpha/beta receptor 2 (515 aa, 58 kDa) is encoded by the human IFNAR2 gene. This protein is involved in interferon signaling.;

NCIt note : Interferon alpha/beta receptor 2 is the beta subunit of the interferon alpha receptor complex, a heterodimeric receptor for type I IFNs, alpha and beta, which also includes interferon alpha/beta receptor 1. Binding of alpha and beta IFNs mediate innate immune responses to viral infection and specific interferon inhibition of virus replication, triggers tyrosine phosphorylation of JAK and STAT proteins, and autophosphorylation of and tyrosine phosphorylation by TYK2. IFNAR2 also interacts with RACK1.;

Details

Origin ID

C37278;

UMLS CUI

C1568206;

Automatic exact mappings (from CISMeF team)
- interferon alpha and beta receptor subunit 2 [ORDO Gene]
- interferon alpha and beta receptor subunit 2 [HGNC gene]
OMIM relation
- Interferon-alpha, -beta, and -omega receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IFNAR2 protein, human [MeSH concept]
- IFNAR2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IFNAR2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Receptor Tyrosine Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bone Remodeling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IFN Alpha Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interferon Alpha Receptor Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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