Interferon Alpha Receptor Complex

Preferred Label : Interferon Alpha Receptor Complex;

NCIt synonyms : Interferon Beta Receptor; Interferon Alpha Receptor; Interferon-Alpha-Beta Receptor;

NCIt definition : Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI);

Details

Origin ID

C37274;

UMLS CUI

C0248648;

Currated CISMeF NLP mapping
- receptor, interferon alpha-beta [MeSH Descriptor]
- receptor, interferon alpha-beta [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Interferon Beta-1A [NCIt concept]
- Interferon Beta-1B [NCIt concept]
- Interferon Beta-1a Inhalation Solution SNG001 [NCIt concept]
- Lyophilized Human Recombinant Interferon-beta 1a FP-1201 [NCIt concept]
- Peginterferon Beta-1A [NCIt concept]
- Recombinant Interferon Alfa-2a [NCIt concept]
- Recombinant Interferon Alfa-2b [NCIt concept]
- Recombinant Interferon Beta [NCIt concept]
- Sampeginterferon Beta-1A [NCIt concept]
gene_product_has_biochemical_function
- Receptor Tyrosine Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
has_gene_product_element
- Interferon Alpha/Beta Receptor 1 [NCIt concept]
- Interferon Alpha/Beta Receptor 2 [NCIt concept]
is_target
- Recombinant Interferon Alfa-2b [NCIt concept]

Keyword's position in hierarchy(ies) :

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