Interferon Beta-1a Inhalation Solution SNG001

Preferred Label : Interferon Beta-1a Inhalation Solution SNG001;

NCIt definition : An inhaled formulation of the endogenous cytokine human interferon (IFN) beta-1a, with potential antiviral and immunomodulating activities. Administrated through inhalation of the nebulized solution, SNG001 targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8 T cells as well as other immune cells. Endogenous IFN-beta-1a is produced following viral infection and it plays a key role in innate immune response against viral pathogens.;

Molecule name : SNG-001; SNG 001;

NCI Metathesaurus CUI : CL1663649;

Details

Origin ID

C180911;

UMLS CUI

C5443462;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Interferon Alpha Receptor Complex [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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