Interferon Beta-1B

Preferred Label : Interferon Beta-1B;

NCIt synonyms : Recombinant interferon beta-1b; Beta-ser-interferon;

NCIt related terms : Betaseron;

NCIt definition : A recombinant and modified form of the endogenous cytokine human interferon (IFN) beta-1b, with antiproliferative, antiviral and immunomodulating activities. Upon administration, interferon beta-1b targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8 T cells as well as other immune cells. Endogenous IFN-beta-1b is produced following viral infection and it plays a key role in innate immune response against viral pathogens.;

UNII : TTD90R31WZ;

CAS number : 145155-23-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 145155-23-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Betaferon; Betaseron;

NSC code : 660166;

Codes from synonyms : NSC0660166;

Details

Origin ID

C2221;

UMLS CUI

C0244713;

Automatic exact mappings (from CISMeF team)
- Interferon beta-1b [ICD-11 Extension code]
- Product containing interferon beta-1b (medicinal product) [SNOMED CT concept]
CISMeF manual mappings
- Interferon beta-1b [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Interferon beta-1b [MeSH Descriptor]
- Interferon beta-1b (substance) [SNOMED CT concept]
- Interferon.beta 1b [LOINC component]
- Product containing interferon beta-1b (medicinal product) [SNOMED CT concept]
- interferon beta-1b [ATC Code]
- interferon beta-1b [International Nonproprietary Name]
- interferon beta-1b [MeSH concept]
Validated automatic mappings to BTNT
- interferon beta-1b [ATC Code]
chemical_or_drug_affects_gene_product
- Interferon Alpha Receptor Complex [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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