Preferred Label : Interferon Alpha/Beta Receptor 1;
NCIt synonyms : IFNBR; IFN-Alpha-REC; IFRC; Alpha-Beta-Omega Interferon Receptor-1; Antiviral Protein Alpha Type; AVP; HuIFN-Alpha-Rec; Interferon Alpha Receptor; Antiviral Protein, Beta-Type; Interferon-Alpha, -Beta, and -Omega Receptor 1; CRF2-1; Interferon-Alpha/Beta Receptor Alpha Chain; Alpha-Type Antiviral Protein; Interferon-Beta Receptor 1; IFN-R-1; Type I Interferon Receptor 1; Cytokine Receptor Family 2 Member 1; IFRC Interferon-Beta Receptor; Beta-Type Antiviral Protein; Cytokine Receptor Class-II Member 1; Interferon Alpha/Beta Receptor Alpha Chain; Human Interferon-Alpha Receptor; Interferon Alpha-Beta Receptor Alpha Chain; Interferon-Alpha-Beta Receptor Alpha Chain; Interferon-Alpha Receptor; IFN-Alpha/Beta Receptor 1; Antiviral Protein, Alpha-Type;
NCIt definition : Interferon alpha/beta receptor 1 (557 aa, 64 kDa) is encoded by the human IFNAR1
gene. This protein plays a role in interferon-dependent signal transduction.;
NCIt note : Interferon alpha/beta receptor 1 Chain contains 3 fibronectin type III domains and
is the alpha subunit of Interferon Alpha Receptor Complex, a heterodimeric receptor
for type I IFNs, alpha and beta, which also includes interferon alpha/beta receptor
2. Binding of alpha and beta IFNs mediate innate immune responses to viral infection
and specific interferon inhibition of virus replication, triggers tyrosine phosphorylation
of JAK and STAT proteins, and autophosphorylation of and tyrosine phosphorylation
by TYK2.;
Origin ID : C37276;
UMLS CUI : C1568204;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
