IL22 Signaling Pathway

Preferred Label : IL22 Signaling Pathway;

NCIt related terms : IL22 Soluble Receptor Signaling Pathway;

Alternative definition : BIOCARTA: IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C. One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation. A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains. The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor. The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses. The IL-22 soluble receptor may act as an anti-inflammatory agent. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il22bppathway;

Details

Origin ID

C39121;

UMLS CUI

C1512592;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Interleukin-10 Receptor Subunit Alpha [NCIt concept]
- Interleukin-22 [NCIt concept]
- Non-Receptor Tyrosine-Protein Kinase TYK2 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Signal Transducer and Activator of Transcription 5A [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
pathway_has_gene_element
- IL10RA wt Allele [NCIt concept]
- IL22 wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- STAT5A wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- TYK2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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