IFN Gamma Signaling Pathway

Preferred Label : IFN Gamma Signaling Pathway;

Alternative definition : BIOCARTA: Interferon gamma is secreted from CD4 Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ifngPathway;

Details

Origin ID

C39112;

UMLS CUI

C1512583;

Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Interferon Gamma [NCIt concept]
- Interferon Gamma Receptor 1 [NCIt concept]
- Interferon Gamma Receptor 2 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Tyrosine-Protein Kinase JAK1 [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IFNGR1 wt Allele [NCIt concept]
- IFNGR2 wt Allele [NCIt concept]
- JAK1 wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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