CCR5 Signaling Pathway

Preferred Label : CCR5 Signaling Pathway;

NCIt related terms : Pertussis toxin-insensitive CCR5 Signaling in Macrophage;

Alternative definition : BIOCARTA: The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release. Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase. Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1. This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_Ccr5Pathway;

Details

Origin ID

C39018;

UMLS CUI

C1511416;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- C-C Chemokine Receptor Type 5 [NCIt concept]
- C-C Motif Chemokine 2 [NCIt concept]
- C-C Motif Chemokine 4 [NCIt concept]
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- Stromal Cell-Derived Factor 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
pathway_has_gene_element
- CCL2 wt Allele [NCIt concept]
- CCL4 wt Allele [NCIt concept]
- CCR5 wt Allele [NCIt concept]
- CXCL12 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GNAQ wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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