Myosin Phosphatase Pathway

Preferred Label : Myosin Phosphatase Pathway;

NCIt synonyms : Myosin Pathway;

NCIt related terms : PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase;

Alternative definition : BIOCARTA: The phosphorylation of myosin affects its role in smooth muscle contraction, platelet formation, and possibly other processes. Phosphorylation by myosin light chain kinase (MLCK) increases myosin activity and dephosphorylation by myosin phosphatase decreases myosin activity. CPI, a factor that binds to and inhibits myosin phosphatase, is a target of phosphorylation by PKC and PKN. The inhibitory activity of CPI is regulated by its own phosphorylation state; when CPI is phosphorylated, its inhibitory activity is increased. The activation of signal transduction cascades such as GPCR pathways can lead to activation of PKC, phosphorylation of CPI, inhibition of myosin phosphatase, increased myosin phosphorylation, and increased smooth muscle contraction or platelet release. The action of histamine in vasoconstriction, for example, may be mediated by activation of PKC through the histamine receptor, resulting in phosphorylation of CPI-17, increased inhibition of myosin phosphatase, and increased smooth muscle contraction. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_myosinPathway;

Details

Origin ID

C39160;

UMLS CUI

C1513801;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-13 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Rho GTPase-Activating Protein 5 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Serine/Threonine-Protein Kinase N1 [NCIt concept]
pathway_has_gene_element
- ARHGAP5 wt Allele [NCIt concept]
- ARHGEF1 wt Allele [NCIt concept]
- GNA12 wt Allele [NCIt concept]
- GNA13 wt Allele [NCIt concept]
- GNAQ wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- PKN1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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