Protein Kinase C Activation Pathway

Preferred Label : Protein Kinase C Activation Pathway;

NCIt related terms : Activation of PKC through G protein coupled receptor;

Alternative definition : BIOCARTA: G-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common signaling systems utilized by GPCRs activates protein kinase C (PKC), a ubiquitous family of serine/threonine protein kinases. The pathway leading to PKC activation starts with a class of GPCRs that interact with and activate Gq G-proteins when the receptor has agonist ligand bound. GPCRs that act through Gq include some muscarinic acetylcholine receptors, many peptide receptors, and the 5-HT2 serotonin receptors. Activated Gq with GTP bound activates its downstream target phospholipase C (PLC) to hydrolyze the membrane lipid PIP2, producing IP3 and diacylglycerol (DAG). IP3 is water-soluble and diffuses through the cytoplasm to the ER, where it binds to and opens a calcium channel, releasing calcium stores from inside the ER into the cytoplasm. Calcium alters many cellular processes, in part by binding to regulatory proteins such as calmodulin and calcineurin. The interaction of both DAG and calcium with PKC activates its kinase activity and the phosphorylation of many different protein targets alters their activity. The involvement of PKC in cellular proliferation and the cell cycle is indicated by the activity of tumor promoters like phorbol esters as PKC activators. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_pkcPathway;

Details

Origin ID

C39190;

UMLS CUI

C1514554;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
pathway_has_gene_element
- GNAQ wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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