Preferred Label : Phospholipid Associated Cell Signaling Pathway;
NCIt related terms : Phospholipase C d1 in phospholipid associated cell signaling;
Alternative definition : BIOCARTA: Phospholipase C (PLC) d1 is a member of the PLC family that produces two
second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by hydrolyzing
the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). DAG in combination
with Ca is necessary for further activation of Protein Kinase C, while IP3 diffuses
into the cytoplasm and mediates the release of intracellular calcium. PLC d1 has a
pleckstrin homology (PH) domain that binds to PIP2 in the membrane with an affinity
of 1.7 mM. It has selectivity for PIP2 over other phosphatidylinositol lipids and
provides a specific probe for activation of PIP2 metabolism to DG and IP3. Activation
of PLC d1 results in its translocation from the membrane to the cytoplasm. PLC d1
activity is feedback-inhibited by IP3, which has an 8-fold higher affinity for PLC
d1 than does PIP2. The members of the PLC family play a key role in the signal transduction
cascade for many receptors. At basal Ca levels PLC d1 has been shown to be activated
by the adrenoreceptor a1B, adrenoreceptor a1D, a-thromboxane receptor and oxytocin
receptor. The G protein involved is the GTP-binding protein known as tissue transglutaminase
(Gah or TGII). Gah is a bifunctional enzyme, having GTPase and transglutaminase (TGase)
activity and is present in the plasma membrane, cytosol, and nucleus. Exchange of
GDP to GTP by Gah is facilitated by activation of the receptors. However, a bimodal
regulation of PLC d1 activity has been observed depending on Ca levels and occupancy
of the guanine nucleotide binding site of Gah. In addition, the GTPase activating
protein RhoGAP interacts with and stimulates PLC d1. The complex regulation of PLC
d1 activity enables the protein to modulate intracellular signaling. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_plcdPathway;
Origin ID : C39192;
UMLS CUI : C1519055;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
