Nitric Oxide Synthase, Inducible

Preferred Label : Nitric Oxide Synthase, Inducible;

NCIt synonyms : Hepatocyte Nitric Oxide Synthase; Nitric Oxide Synthase-2A; Inducible Nitric Oxide Synthase; HEP-NOS; NOS2; NOS Type II; NOS; NOS2A; Macrophage Nitric Oxide Synthase; iNOS; Hepatocyte NOS; Inducible NOS; Inducible NO Synthase; Nitric Oxide Synthase 2A; Peptidyl-Cysteine S-Nitrosylase NOS2; EC 1.14.13.39;

NCIt definition : Nitric oxide synthase, inducible (1153 aa, 131 kDa) is encoded by the human NOS2A gene. This protein is involved in both nitric oxide biosynthesis and arginine metabolism.;

NCIt note : Calcium/calmodulin stimulated homodimeric nitric oxide synthase, inducible binds FAD and FMN cofactors, contains a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine).;

Details

Origin ID

C38565;

UMLS CUI

C0669372;

Currated CISMeF NLP mapping
- HEP (body structure) [SNOMED CT concept]
False automatic mappings
- Hepatoerythropoietic porphyria [ORDO Disease]
OMIM relation
- Nitric oxide synthase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- NOS2 protein, human [MeSH concept]
- NOS2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- NOS2 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Arginine and Proline Metabolism Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- PPAR-alpha Gene Regulation Pathway [NCIt concept]
- Peroxisome Biogenesis Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Bardoxolone Methyl [NCIt concept]
- Fluorine F 18 NOS [NCIt concept]
- iNOS Dimerization Inhibitor FK-330 [NCIt concept]

Keyword's position in hierarchy(ies) :

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