Interleukin-1 Receptor Type 2

Preferred Label : Interleukin-1 Receptor Type 2;

NCIt synonyms : CD121 Antigen-Like Family Member B; Interleukin-1 Receptor Beta Type-II; IL-1 Type II Receptor; IL-1R-Beta; IL-1R-2; Interleukin-1 Receptor Type II; CD121b; Antigen CDw121b; IL-1RT-2; Interleukin-1 Receptor Beta; CDw121b; IL-1RT2; Interleukin-1-Receptor Beta Type-II; Interleukin 1 Receptor Type II; CD121b Antigen;

NCIt definition : Interleukin-1 receptor type 2 (398 aa, 45 kDa) is encoded by the human IL1R2 gene. This protein plays a role in both interleukin-1 binding and the inhibition of signaling.;

NCIt note : Interleukin-1 receptor type 2 is a type I membrane protein decoy cytokine receptor that contains 3 IgC2 domains and inhibits the activity of its ligands IL1A, IL1B, and IL1R1/IL1RA.;

Details

Origin ID

C38914;

UMLS CUI

C1701550;

Automatic exact mappings (from CISMeF team)
- Interleukin 1 receptor, type II [OMIM gene]
- receptors, Interleukin-1 type II [MeSH concept]
- receptors, interleukin-1 type ii [MeSH Descriptor]
OMIM relation
- Interleukin 1 receptor, type II [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL1R2 protein, human [MeSH concept]
- IL1R2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL1R2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Interleukin-1-beta New Formulation [NCIt concept]
- Recombinant Interleukin-1-alpha [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Interleukin Signaling [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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