Recombinant Interleukin-1-alpha

Preferred Label : Recombinant Interleukin-1-alpha;

NCIt synonyms : interleukin-1-alpha;

NCIt related terms : IL-1-alfa;

NCIt definition : A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1 precursor is produced by monocytes, activated macrophages, and other cell types; mature IL-1 is generated by proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent enhances T cell proliferation and B cell growth and differentiation and induces the expression of proinflammatory cytokines. (NCI04);

Codes from synonyms : CDR0000044416;

Details

Origin ID

C1754;

UMLS CUI

C1523980;

Currated CISMeF NLP mapping
- Interleukin 1 alpha [LOINC component]
- Interleukin-1 alpha (substance) [SNOMED CT concept]
- Interleukin-1alpha [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- Interleukin-1alpha [MeSH Descriptor]
chemical_or_drug_affects_cell_type_or_tissue
- Lymphocyte [NCIt concept]
chemical_or_drug_affects_gene_product
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor Type 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cytokine Signaling Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Lymphocyte Activation Process [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Etoposide/Ifosfamide/Interleukin-1-Alpha [NCIt concept]
- Carboplatin/Interleukin-1-Alpha [NCIt concept]
- Carboplatin/Interleukin-1-Alpha/Methylene Blue [NCIt concept]
- Cisplatin/Interleukin-1-Alpha [NCIt concept]
- Cyclophosphamide/Interleukin-1-Alpha [NCIt concept]
- Dacarbazine/Interleukin-1-Alpha [NCIt concept]
- Etoposide/Interleukin-1-Alpha [NCIt concept]
- Indomethacin/Interleukin-1-Alpha [NCIt concept]
- Indomethacin/Interleukin-1-Alpha/Etoposide [NCIt concept]
- Interleukin-1-Alpha/Interleukin-2 [NCIt concept]
- Interleukin-1-Alpha/Methotrexate [NCIt concept]
is_related_to_endogenous_product
- Interleukin-1 Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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