Interleukin-1 Receptor Type 1

Preferred Label : Interleukin-1 Receptor Type 1;

NCIt synonyms : CD121 Antigen-Like Family Member A; Interleukin-1 Receptor Type I; IL-1R-1; CD121a; IL-1RT-1; IL-1RT1; CD121a Antigen; IL-1R-Alpha; p80; Interleukin-1 Receptor Alpha Type-I; Interleukin-1 Receptor Alpha; Interleukin-1-Receptor Alpha Type-I;

NCIt definition : Interleukin-1 receptor type 1 (569 aa, 65 kDa) is encoded by the human IL1R1 gene. This protein is involved in interleukin-1 binding and the positive regulation of signal transduction.;

NCIt note : Interleukin-1 receptor type 1 is a type I membrane protein cytokine receptor for IL1A and IL1B, binds to IL1RAP, and contains 3 IgC2 domains and 1 TIR domain. Agonist binding leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation.;

Details

Origin ID

C38912;

UMLS CUI

C1700970;

Automatic exact mappings (from CISMeF team)
- Interleukin 1 receptor alpha [OBSOLETE LOINC component]
- Interleukin 1 receptor, type I [OMIM gene]
- WD repeat domain 48 [ORDO Gene]
- Wd repeat-containing protein 48 [OMIM gene]
- receptors, Interleukin-1 type I [MeSH concept]
- receptors, interleukin-1 type i [MeSH Descriptor]
OMIM relation
- Interleukin 1 receptor, type I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL1R1 protein, human [MeSH concept]
- IL1R1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL1R1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Recombinant Interleukin-1-alpha [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anakinra [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients