Interleukin-12 Subunit Beta

Preferred Label : Interleukin-12 Subunit Beta;

NCIt synonyms : IL12B; Interkeukin-12 beta chain; Natural Killer Cell Stimulatory Factor-2; Interleukin 12, p40; Cytotoxic Lymphocyte Maturation Factor 2, p40; IL23, subunit p40; Interleukin 12B; IL-12 Subunit P40; IL12, Subunit p40; Interleukin-12B; IL-12p40; IL12-p40; NK Cell Stimulatory Factor Chain 2; CLMF p40; Interleukin-12 Beta Chain; Natural Killer Cell Stimulatory Factor, 40 kD Subunit; Cytotoxic Lymphocyte Maturation Factor 2; Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit; Interleukin 23, p40 Subunit; Natural Killer Cell Stimulatory Factor 2;

NCIt definition : Interleukin-12 subunit beta (328 aa, 37 kDa) is encoded by the human IL12B gene. This protein is involved in the growth of both natural killer cells and T-cells.;

NCIt note : Interleukin-12 subunit beta can form a heterodimer with either interleukin-12 subunit alpha, called interleukin-12, or with interleukin-23 subunit alpha, called interleukin-23.;

Details

Origin ID

C28509;

UMLS CUI

C1099914;

Currated CISMeF NLP mapping
- Interleukin-12B [FMA entity]
OMIM relation
- Interleukin 12b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- IL12B protein, human [MeSH Supplementary Concept]
- IL12B protein, human [MeSH concept]
- Interleukin-12B [FMA entity]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- IL12B Gene [NCIt concept]
- Interleukin Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Protein Complex Subunit [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interleukin-12 [NCIt concept]
- Interleukin-23 [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cell-Mediated Immunity [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- NK Cell Activation [NCIt concept]
- T-Cell Activation [NCIt concept]
is_target
- Ustekinumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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