Interleukin-12

Preferred Label : Interleukin-12;

NCIt synonyms : Interleukin 12; IL-12; CLMF; Natural Killer Cell Stimulatory Factor; NKSF; IL12; Cytotoxic Lymphocyte Maturation Factor; IL-12 p70; IL-12p70;

NCIt definition : Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI);

Details

Origin ID

C20514;

UMLS CUI

C0123759;

Automatic exact mappings (from CISMeF team)
- Interleukin 1+2 [LOINC component]
- Interleukin 12a [OMIM gene]
- interleukin 12A [HGNC gene]
- interleukin 12A [ORDO Gene]
- interleukin 12B [HGNC gene]
- interleukin 12B [ORDO Gene]
- interleukin-12 [Artificial nutrition thesaurus concept]
- interleukin-12 receptor binding [GO term]
Currated CISMeF NLP mapping
- Interleukin 12 [LOINC component]
- Interleukin-12 [FMA entity]
- Interleukin-12 [MeSH Descriptor]
- Interleukin-12 [MeSH concept]
- interleukin-12 [SNOMED Notion]
False automatic mappings
- Interleukin-12 (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Interleukin 12 [LOINC component]
- Interleukin-12 [FMA entity]
- Interleukin-12 [MeSH concept]
- Interleukin-12 [MeSH Descriptor]
- Interleukin-12 (substance) [SNOMED CT concept]
- interleukin-12 [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Interleukin [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell-Mediated Immunity [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- NK Cell Activation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_gene_product_element
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
is_target
- Ad-RTS-hIL-12 [NCIt concept]

Keyword's position in hierarchy(ies) :

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