Interleukin-12

Preferred Label : Interleukin-12;

MeSH definition : A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.;

MeSH synonym : il12; il-12; il 12; interleukin 12; Natural Killer Cell Stimulatory Factor; Cytotoxic Lymphocyte Maturation Factor; IL-12 p70; Interleukin-12 p70; Interleukin 12 p70;

CISMeF synonym : cytotoxic lymphocyte maturation factor; edodekin alfa; interleukin-12 p70; natural killer cell stimulatory factor; p70, interleukin-12;

MeSH hyponym : Interleukin 12 p70; IL-12 p70;

Registry Number MeSH : 187348-17-0;

MeSH annotation : DF: IL 12 or IL12;

Wikipedia link : https://en.wikipedia.org/wiki/Il12;

Is substance : O;

Details

Origin ID

D018664;

UMLS CUI

C0123759;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Edodekin alfa [NCIt concept]
- Interleukin 1+2 [LOINC component]
- Interleukin 12 Measurement [NCIt concept]
- Interleukin 12a [OMIM gene]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Twelfth (qualifier value) [SNOMED CT concept]
- interleukin 12A [HGNC gene]
- interleukin 12B [HGNC gene]
- interleukin-12 [Artificial nutrition thesaurus concept]
- interleukin-12 receptor binding [GO term]
Currated CISMeF NLP mapping
- Interleukin 12 [LOINC component]
- Interleukin-12 [FMA entity]
- Interleukin-12 [NCIt concept]
- Interleukin-12 (substance) [SNOMED CT concept]
- interleukin-12 [SNOMED Notion]
Indexing information
- 12-hydroxyscabrolide A [MeSH Supplementary Concept]
- scabrolide C [MeSH Supplementary Concept]
Pharmacological action(s)
- adjuvants, immunologic [MeSH Descriptor]
- angiogenesis inhibitors [MeSH Descriptor]
Record concept(s)
- Edodekin Alfa [MeSH concept]
- Interleukin-12 [MeSH concept]
Related MeSH Supplementary Concept(s)
- 99mTc-HYNIC-interleukin-12 [MeSH Supplementary Concept]
- Flexi-12 protein, human [MeSH Supplementary Concept]
- GEN-1 [MeSH Supplementary Concept]
- IL-12 p80, mouse [MeSH Supplementary Concept]
- NHS-IL12 immunocytokine [MeSH Supplementary Concept]
See also
- Ustekinumab [MeSH Descriptor]
- immunity, cellular [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Interleukin 12 [LOINC component]
- Interleukin-12 [FMA entity]
- Interleukin-12 [NCIt concept]
- Interleukin-12 (substance) [SNOMED CT concept]
- interleukin-12 [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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