" /> Edodekin alfa - CISMeF





Preferred Label : Edodekin alfa;

NCIt synonyms : Recombinant human interleukin-12 (IL-12) cytokine; Cytotoxic Lymphocyte Maturation Factor; Natural Killer Cell Stimulatory Factor; Therapeutic Interleukin-12; NM-IL-12;

NCIt related terms : Interleukin-12; IL-12; Interleukin 12;

NCIt definition : A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Edodekin alfa binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04);

Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages. It causes other immune cells to make cytokines and increases the growth of T lymphocytes. It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-12 is a type of cytokine.;

UNII : 31Z82G8ME1;

CAS number : 187348-17-0;

Molecule name : Ro 24-7472;

NSC code : 672423;

Codes from synonyms : 09122; NSC0672423; CDR0000045426; CDR0000044418;

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30/07/2025


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