NCIt related terms : Interleukin-12; IL-12; Interleukin 12;
NCIt definition : A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential
antineoplastic activity. Edodekin alfa binds to and activates its cell-surface receptor,
stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible
protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04);
Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells)
and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages.
It causes other immune cells to make cytokines and increases the growth of T lymphocytes.
It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory
is used as a biological response modifier to boost the immune system in cancer therapy.
Interleukin-12 is a type of cytokine.;
UNII : 31Z82G8ME1;
CAS number : 187348-17-0;
Molecule name : Ro 24-7472;
NSC code : 672423;
Codes from synonyms : 09122; NSC0672423; CDR0000045426; CDR0000044418;