Interleukin 12 Receptor

Preferred Label : Interleukin 12 Receptor;

NCIt synonyms : Interleukin 12 Receptor Beta; High Affinity Interleukin 12 Receptor; High Affinity Interleukin 12 Receptor Beta; Interleukin-12 Receptor; IL12R; IL-12R;

NCIt definition : Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI);

UNII : 35PXZ22YJE;

Details

Origin ID

C38915;

UMLS CUI

C1527265;

Automatic exact mappings (from CISMeF team)
- interleukin-12 receptor activity [GO term]
Currated CISMeF NLP mapping
- receptors, Interleukin-12 [MeSH concept]
- receptors, interleukin-12 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Edodekin alfa [NCIt concept]
- pNGVL3-hIL12 [NCIt concept]
gene_product_has_biochemical_function
- Cytokine Receptor [NCIt concept]
has_gene_product_element
- Interleukin-12 Receptor Subunit Beta-1 [NCIt concept]
- Interleukin-12 Receptor Subunit Beta-2 [NCIt concept]
is_target
- Edodekin alfa [NCIt concept]
- IL-12-expressing Exosome CDK-003 [NCIt concept]
- IL-2/IL-12-based Fusion Protein CLN-617 [NCIt concept]
- Interleukin-12-Fc Fusion Protein DF6002 [NCIt concept]

Keyword's position in hierarchy(ies) :

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