Preferred Label : IL-12-expressing Exosome CDK-003;
NCIt synonyms : IL-12-displaying Therapeutic Exosome CDK-003; IL-12/PTGFRN-expressing Exosome CDK-003;
NCIt definition : Exosome engineered to display the human pro-inflammatory cytokine interleukin-12 (IL-12)
in a fully active form on the surface via the exosome surface glycoprotein prostaglandin
F2 receptor negative regulator (PTGFRN; CD315), with potential immunostimulating and
antineoplastic activities. Upon intralesional administration of IL-12-expressing exosome
CDK-003, IL-12 expressed by the exosome may activate the immune system in the tumor
microenvironment (TME) by promoting the activation of natural killer (NK) cells, inducing
secretion of interferon-gamma (IFN-g) and inducing cytotoxic T-lymphocyte (CTL) responses
against tumor cells. This may result in immune-mediated tumor cell death, inhibition
of tumor cell proliferation and inhibition of tumor angiogenesis. The exosome-based
formulation may provide targeted anti-tumor immunity while minimizing off-target toxicity.
PTGFRN, expressed on the surface of the exosome, enables the engagement of the IL-12
receptor (IL-12R) on immune effector cells such as T-cells and NK cells.;
Drug name : exoIL-12;
Molecule name : CDK 003; CDK-003;
NCI Metathesaurus CUI : CL1778252;
Origin ID : C185871;
UMLS CUI : C5667038;
Semantic type(s)
- concept_is_in_subset
- has_target
