Preferred Label : IL-2/IL-12-based Fusion Protein CLN-617;
NCIt synonyms : IL-2/LAIR2/HSA/IL-12-containing Fusion Protein CLN-617;
NCIt definition : A single-chain fusion protein composed of the human cytokine interleukin-2 (IL-2),
the collagen-binding domain leukocyte-associated immunoglobulin-like receptor 2 (LAIR2),
linked, through glycine/serine linkers, to human serum albumin (HSA) and human IL-12,
with potential immunoregulatory and antineoplastic activities. Upon intratumoral (IT)
administration of CLN-617, both the IL-2 and IL-12 moieties bind to their respective
receptors expressed on CD8 T-cells and natural killer (NK) cells in the tumor microenvironment
(TME), thereby activating IL-2- and IL-12-mediated signaling. This synergistically
activates and expands CD8 T-cells and NK cells and leads to cytolytic immune responses
against tumor cells, which kills tumor cells and inhibits tumor cell proliferation,
and triggers systemic anti-tumor immunity. LAIR2 and HSA specifically retain CLN-617
in the injected tumor by binding collagen and increasing molecular weight (MW), respectively.
The specific delivery and retention into the tumor increase efficacy of CLN-617 while
sparing the unwanted toxic effects of IL-2 and IL-12.;
Molecule name : CLN 617; CLN-617;
NCI Metathesaurus CUI : CL1920790;
Origin ID : C201584;
UMLS CUI : C5907912;
Semantic type(s)
- concept_is_in_subset
- has_target
