Interleukin-12 Receptor Subunit Beta-1

Preferred Label : Interleukin-12 Receptor Subunit Beta-1;

NCIt synonyms : Interleukin-12 Receptor Beta-1 Chain; CD212 Antigen; IL-12RB1; Interleukin-12-Receptor Beta-1-Chain; IL-12R-Beta-1; IL-12 Receptor Beta Component; IL-12 Receptor Subunit Beta-1; IL-12R Subunit Beta-1;

NCIt definition : Interleukin-12 receptor subunit beta-1 (662 aa, 73 kDa) is encoded by the human IL12RB1 gene. This protein plays a role in interleukin-12 binding and signal transduction.;

NCIt note : Interleukin-12 receptor subunit beta-1 is a type I transmembrane disulfide-linked dimer/oligomer containing 5 fibronectin type-III domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of IL12RB1 and IL12RB2. Heterodimers containin one IL12RB1 and one IL23R are receptors for interleukin-23. (UniProt);

Details

Origin ID

C38917;

UMLS CUI

C1700851;

Automatic exact mappings (from CISMeF team)
- Interleukin 12 receptor, beta-1 [OMIM gene]
- Interleukin-12 receptor beta 1 subunit [MeSH concept]
- interleukin 12 receptor subunit beta 1 [ORDO Gene]
- interleukin-12 receptor beta 1 subunit [MeSH Descriptor]
OMIM relation
- Interleukin 12 receptor, beta-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL12RB1 protein, human [MeSH concept]
- IL12RB1 protein, human [MeSH Supplementary Concept]
- Interleukin-12 receptor beta 1 subunit [MeSH concept]
- interleukin-12 receptor beta 1 subunit [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL12RB1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Protein Complex Subunit [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
gene_product_is_physical_part_of
- Interleukin 12 Receptor [NCIt concept]
- Interleukin-23 Receptor Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Adenoviral Transduced hIL-12-expressing Autologous Dendritic Cells INXN-3001 Plus Activator Ligand INXN-1001 [NCIt concept]
- Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001 [NCIt concept]
- IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic Viral Vector TG6050 [NCIt concept]

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