Preferred Label : Adenovirus-mediated Human Interleukin-12 INXN-2001 Plus Activator Ligand INXN-1001;
NCIt synonyms : Ad-RTS-IL-12 Plus AL;
NCIt definition : A replication incompetent adenovirus encoding the human pro-inflammatory cytokine
interleukin-12 (IL-12) (INXN-2001) in combination with the proprietary activator ligand
INXN-1001, with potential immunomodulating and antineoplastic activities. Production
of IL-12 is controlled by an inducible DNA element that allows transcription initiation
only in the presence of the ligand inducer. Upon intratumoral administration of INXN-2001
and oral administration of INXN-1001, INXN-1001 is able to induce expression of IL-12
from INXN-2001. IL-12 expressed by the adenovirus may activate the immune system by
promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma
and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated
tumor cell death and inhibition of tumor cell proliferation.;
Molecule name : ZIN ATI-001; INXN-2001/1001;
NCI Metathesaurus CUI : CL430563;
Origin ID : C97959;
UMLS CUI : C3273724;
Semantic type(s)
- concept_is_in_subset
- has_target
