Preferred Label : IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic Viral Vector TG6050;
NCIt synonyms : VV-expressing IL-12/Anti-CTLA4 Antibody TG6050; IL-12/Anti-CTLA-4 Monoclonal Antibody-expressing Oncolytic VV TG6050; Oncolytic Vaccinia Virus Expressing IL-12/Anti-CTLA4 Antibody TG6050;
NCIt definition : A genetically engineered oncolytic vaccinia viral (VV) vector expressing the human
immunostimulating cytokine interleukin-12 (IL-12) and a full-length antibody directed
against the human inhibitory T-cell-expressed receptor cytotoxic T-lymphocyte-associated
antigen 4 (CTLA-4; CTLA4), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon intavenous administration, IL-12/anti-CTLA-4 monoclonal antibody-expressing
oncolytic VV TG6050 specifically infects and replicates in tumor cells causing viral-mediated
tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells, thereby further killing tumor cells. Tumor antigens released from the
lysed tumor cells also activate the immune system to induce a tumor-specific systemic
immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby non-infected
tumor cells. In addition, the expression of IL-12 promotes the activation of natural
killer (NK) cells, which induces the secretion of interferon-gamma and a CTL-mediated
response against uninfected tumor cells. This results in immune-mediated tumor cell
death and further inhibition of tumor cell proliferation. The anti-CTLA-4 antibody
released by the infected cells targets and binds to CTLA-4 expressed on T-cells and
inhibits the CTLA-4-mediated downregulation of T-cell activation, which promotes T-cell
activation and further enhances a CTL-mediated anti-tumor immune response. CTLA-4,
an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays
a key role in the downregulation of the immune system.;
Molecule name : TG6050; TG- 6050;
NCI Metathesaurus CUI : CL1907548;
Origin ID : C200558;
concept_is_in_subset
- has_target
