" /> Cytotoxic T-Lymphocyte Protein 4 - CISMeF





Preferred Label : Cytotoxic T-Lymphocyte Protein 4;

NCIt synonyms : CTLA4 Protein; CTLA4; CD152 Antigen; Cytotoxic T-Lymphocyte-Associated Antigen 4; CTLA-4; Cytotoxic T Lymphocyte-Associated Protein 4; Cytotoxic T-Lymphocyte-Associated Protein-4; CD152; Cytotoxic T-Lymphocyte-Associated Serine Esterase-4; Cytotoxic T-Lymphocyte-Associated Protein 4;

NCIt definition : Cytotoxic T-lymphocyte protein 4 (223 aa, 25 kDa) is encoded by the human CTLA4 gene. This protein is involved in the inhibition of T-cell mediated immune responses.;

NCIt note : CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells that shares significant homology and ligand specificity with CD28. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation and CTLA-4 binds to B7 with a greater affinity. B7 antigen presenting cells regulate T-cell activation by delivering stimulatory signals through CD28 and inhibitory signals through CTLA-4. A CTLA-4 splice variant with a deleted transmembrane segment (soluble CTLA-4 or sCTLA-4) is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. (OMIM);

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08/05/2024


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