Preferred Label : Anti-CTLA-4 Monoclonal Antibody-IL-15/IL-15Ra Fusion Protein JK08;
NCIt synonyms : Fusion Protein JK08;
NCIt definition : A recombinant fusion protein consisting of a human monoclonal antibody directed against
cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4) fused to the immunostimulatory
cytokine interleukin-15 (IL-15) cross-linked with the sushi domain of IL-15 receptor
alpha (IL-15Ra), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration of anti-CTLA-4 monoclonal antibody-IL-15/IL-15Ra fusion protein
JK08, the monoclonal antibody domain targets and binds to CTLA-4 expressed on T-cells
and inhibits the CTLA-4-mediated downregulation of T-cell activation. The IL-15/IL-15Ra
complex targets and binds to CD8 T and natural killer (NK) cells, thereby increasing
their activation and proliferation. Altogether, this leads to an inhibition of regulatory
T-cell (Tregs)-mediated immunosuppression, induces antibody-dependent cellular cytotoxicity
(ADCC), increases memory T-cells and enhances a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells. CTLA-4, an inhibitory receptor and member of
the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the
immune system.;
Molecule name : JK-08; JK 08;
NCI Metathesaurus CUI : CL1905846;
Origin ID : C198686;
concept_is_in_subset
- has_target
