" /> Vudalimab - CISMeF





Preferred Label : Vudalimab;

NCIt synonyms : PD-1 x CTLA-4 Bispecific Antibody XmAb20717; Anti-PD-1/Anti-CTLA-4 XmAb20717; PD-1 x CTLA-4 Dual Checkpoint Inhibitor XmAb20717; Anti-PD1/CTLA4 Bispecific Antibody XmAb20717;

NCIt definition : A Fc-engineered bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, vudalimab targets and binds to both PD-1 and CTLA4 expressed on tumor-infiltrating T-lymphocytes (TILs) and inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD1 and CTLA4 with XmAb20717 may enhance T cell activation and proliferation more than the blockade of either immune checkpoint receptor alone. The engineered Fc domain increases the stability and half-life of the antibody.;

UNII : 4I9I5X3Z6N;

CAS number : 2329669-72-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2329669-72-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : XmAb20717; XmAb 20717;

NCI Metathesaurus CUI : CL552206;

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15/05/2024


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