NCIt definition : An immunoglobulin G1 (IgG1) monoclonal antibody directed against the human T-cell
receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint
inhibitory and antineoplastic activities. Upon administration, tuvonralimab binds
to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of
T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response
against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily, plays a key role in the downregulation of the immune system.;
Semantic type(s)