Preferred Label : Anti-CTLA-4 Monoclonal Antibody GIGA-564;
NCIt synonyms : Anti-CTLA4 Monoclonal Antibody GIGA-564;
NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody directed against the human T-cell-expressed
receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4; CTLA4; CD152), with
potential immunomodulatory and antineoplastic activities. Upon administration, anti-CTLA-4
monoclonal antibody GIGA-564 targets and binds to CTLA-4, and may induce Fc receptor
(FcR) signaling. This may deplete regulatory T-cells (Tregs) in the tumor microenvironment
(TME), decrease the proliferation of the remaining Tregs in the TME, and reactivate
antitumor immune responses. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system. GIGA-564
has limited checkpoint inhibitory activity as it only weakly blocks the interaction
between CTLA-4 and its B7 ligands CD80 and CD86.;
Molecule name : GIGA 564; GIGA-564;
Origin ID : C209757;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
