NCIt definition : A Fc-modified monoclonal antibody directed against the human T-cell receptor cytotoxic
T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon administration, anti-CTLA4 monoclonal
antibody BMS-986218 targets and binds to CTLA4 expressed on T-cells and inhibits the
CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte
(CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor
and member of the immunoglobulin superfamily, plays a key role in the downregulation
of the immune system. Removal of the fucose sugar units from the antibody's Fc region,
enhances its activity and decreases the toxicity of BMS-986218.;
Semantic type(s)