NCIt related terms : Anti-CTLA-4 Monoclonal Antibody AGEN1884;
NCIt definition : A recombinant human monoclonal antibody directed against the human T-cell receptor
cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory
and antineoplastic activities. Upon administration, zalifrelimab binds to CTLA-4 expressed
on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This
leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells.
CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily, plays
a key role in the downregulation of the immune system.;
Semantic type(s)