Preferred Label : Abatacept;

NCIt synonyms : CTLA4-Ig; CTL A4-Ig B7 Inhibitor; cytotoxic T lymphocyte-associated antigen-4;

NCIt definition : A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.;

UNII : 7D0YB67S97;

CAS number : 332348-12-6;

Drug name : Orencia;

Molecule name : BMS-188667; RG2077;

NSC code : 710084;

Details


Main resources

You can consult :


https://www.rheuma-net.ch/fr/doc/abatacept-2/viewdocument/356
2024
Switzerland
guideline
Abatacept
abatacept
Abatacept
Background Treatment

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08/05/2025


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