Abatacept - CISMeF

Preferred Label : Abatacept;

NCIt synonyms : CTLA4-Ig; CTL A4-Ig B7 Inhibitor; cytotoxic T lymphocyte-associated antigen-4;

NCIt definition : A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.;

UNII : 7D0YB67S97;

CAS number : 332348-12-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 332348-12-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Orencia;

Molecule name : BMS-188667; RG2077;

NSC code : 710084;

Details

Origin ID

C28898;

UMLS CUI

C1619966;

Automatic exact mappings (from CISMeF team)
- Abatacept [ICD-11 Extension code]
- CTLA-4 antigen [MeSH concept]
- CTLA-4 antigen [MeSH Descriptor]
- CTLA-4-Ig [MeSH concept]
CISMeF manual mappings
- Abatacept [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Abatacept [MeSH Descriptor]
- Abatacept (substance) [SNOMED CT concept]
- Product containing abatacept (medicinal product) [SNOMED CT concept]
- abatacept [ATC Code]
- abatacept [International Nonproprietary Name]
- abatacept [MeSH concept]
Validated automatic mappings to BTNT
- abatacept [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Cytotoxic T-Lymphocyte Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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