NCIt definition : A human monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic
T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint
inhibitory and antineoplastic activities. Upon intravenous administration, firastotug
targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated
downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory
receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in
the downregulation of the immune system.;
Semantic type(s)