Preferred Label : Anti-CTLA4 MoAb RNA-transfected Autologous Dendritic Cell Vaccine;
NCIt synonyms : anti-CTLA-4 mAb Heavy and Light Chain RNA-transfected Autologous DC; antiCTLA4 RNA DC;
NCIt definition : An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory
activity. Anti-CTLA4 MoAb RNA-transfected autologous DC vaccine is prepared by transfecting
DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic
T-Lymphocyte-Associated Antigen 4); expression of anti-CTLA4 blocks the inhibitory
effect of CTLA4 on the activation of T-lymphocytes. Co-vaccination of this vaccine
with melanoma antigen specific vaccine may eliminate the adverse effects associated
with systemic administration of immune modulators, while also enhancing vaccine-induced
immune responses.;
Origin ID : C94217;
UMLS CUI : C2986402;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
