NCIt definition : A bispecific antibody directed against the human negative immunoregulatory checkpoint
receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated
antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration, caldonirimab targets and binds to both PD-1 and CTLA4
expressed on tumor-infiltrating T lymphocytes (TILs), and inhibits the PD-1- and CTLA4-mediated
downregulation of T-cell activation and proliferation. This restores immune function
and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment
(TME) and negatively regulate the activation and effector functions of T-cells. They
play key roles in the downregulation of the immune system and tumor evasion from host
immunity.;
Semantic type(s)