Preferred Label : Anti-CTLA4 MoAb RNA/GITRL RNA-transfected Autologous Dendritic Cell Vaccine;
NCIt synonyms : anti-CTLA-4 mAb Heavy and Light Chain RNA/GITRL RNA-transfected Autologous DC; GITRL/antiCTLA4 RNA DC;
NCIt definition : An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory
activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting
DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic
T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand)
superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory
effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates
T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma
antigen specific vaccine may eliminate the adverse effects associated with systemic
administration of immune modulators, while also enhancing vaccine-induced immune responses.;
NCI Metathesaurus CUI : CL426031;
Origin ID : C94218;
UMLS CUI : C2986403;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
